Feeling older than your chronological age: A powerful emotional experience for the 45-65 Canadian demographic. Not a specific symptom but a pervasive sense that energy, vitality, and resilience are declining faster than expected.

Treatment strategies of OA include both non-pharmacological and pharmacological therapies. Among pharmacological therapies, analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) are current treatment options for OA because of their well-established effectiveness. However, they act as symptomatic treatments without offering disease modification of OA, and they are accused for increased risk adverse events. For this reason, attention has recently been focused on an ideal treatment, which can improve the clinical symptoms of OA with better tolerability and safety profiles, such as symptomatic slow-acting drugs (SYSADOAs).

Glucosamine and chondroitin, as important medicine in those SYSADOA, are naturally occurring compounds in the body functioning as the principal substrates in the biosynthesis of proteoglycan.